Retinal Pigment Epithelial Cells Synthesize Laminins, Including Laminin 5, and Adhere to Them through 3- and 6-Containing Integrins
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چکیده
PURPOSE. Retinal diseases are often accompanied by changes in the structure of the multilayered extracellular matrix underlying the retina, Bruch’s membrane (BrM). These structural revisions potentially lead to alterations in retinal pigment epithelium (RPE) adhesion, likely via modification of interactions with extracellular matrix (ECM) proteins including laminins in BrM. The purpose of this study was to identify specific laminins in BrM and their receptors in RPE cells.
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تاریخ انتشار 2006